为寻找与口腔粘膜白斑恶变的有关因素,作者在25年期间(1946—1971年)先后对520例口腔粘膜白斑的病人进行观察,平均观察年限为8.7年。资料和方法:所收治的每一病例均有详细记录,包括既往症、临床情况、有关发病因素如吸烟、嗜酒、梅毒和机械刺激,如果病人口腔中有不同金属的修复体,则测其电位差,差值超过50mv者,即认为有损害作用。 To find out the related factors of malignant leukoplakia in the oral mucosa, the authors observed 520 patients with leukoplakia in the 25-year period (1946-1971). The average observation period was 8.7 years. Materials and Methods: Detailed records of each case received, including past symptoms, clinical conditions, and associated risk factors such as smoking, alcohol abuse, syphilis, and mechanical irritation. If the patient’s oral cavity has a different metal restoration, measure the potential. If the difference is more than 50mv, it is considered to have a detrimental effect.