富马酸二甲酯(简称DMF)是一种新型防霉防腐剂。应用于食品、饲料等的防霉保鲜。本文报道了DMF的大鼠急性毒性、蓄积毒性和三种体内、体外致突变性研究的结果。实验证明DMF的大鼠急性毒性较低,口服LD_(50)为2500mg/kg。蓄积毒性实验中蓄积系数为3.3属中等程度蓄积。Ames试验、小鼠精子畸变实验和小鼠骨髓嗜多染红细胞微核实验结果均为阴性。 Dimethyl fumarate (DMF) is a new mildew preservative. Used in food, feed mold preservation. This paper reports the acute toxicity, accumulative toxicity and the results of three in vitro and in vivo mutagenic studies in DMF rats. Experiments show that the acute toxicity of DMF in rats is low, oral LD_ (50) is 2500mg / kg. Accumulation toxicity test in the accumulation coefficient of 3.3 moderate accumulation. Ames test, mouse sperm aberration test and mouse bone marrow polychromatic erythrocyte micronucleus test results were negative.