目的 :探索肝硬化条件下合理的肝静脉阻断方式。方法 :分别缝扎或间歇阻断肝硬化小猪各 6头 ,动态观察肝脏组织病理学、肝功能、肝动脉造影、核素扫描和肝脏血流动力学的改变。结果 :缝扎组早期肝损害明显 ,6周后恢复 ;早期肝右叶肿胀淤血 ,晚期有萎缩 ;左叶横径纵径增加 ;术后门静脉压力升高 ,门静脉血流减慢、流量减少 ;肝动脉血流加快、血流量增加 ;肝动脉 -门静脉瘘、右肝门静脉分支与左肝静脉分支交通支形成。间歇阻断组肝损害较轻但持久 ,阻断期肝右叶肿胀 ,放松后改善 ;6周后左叶略增大 ,右叶减小不明显 ;阻断期 PVP、门静脉、肝动脉血流速度、血流量改变与结扎组相似 ,间歇期恢复 ;未见血管瘘形成。结论 :肝硬化情况下缝扎 RHV致肝右叶萎缩、左叶代偿增生较间歇阻断组明显 ;缝扎 RHV致肝功能损害早期较明显 ,可自行恢复 ,间歇阻断致肝功能损害较轻但持久 ;缝扎 RHV对肝脏血流动力学的影响较明显 ,肝内侧支循环较完善。 Objective: To explore a reasonable way of hepatic vein occlusion under cirrhosis. Methods: Six chickens with cirrhosis were sutured or intermittently, respectively. The changes of liver histopathology, liver function, hepatic artery angiography, radionuclide scanning and hepatic hemodynamics were observed dynamically. Results: The early liver damage in the suture group was obvious and recovered after 6 weeks. The swelling and congestion in the early right lobe of the liver were delayed and atrophy was observed in the suture group. The transverse diameter of the left lobe increased, the pressure of the portal vein increased, Hepatic artery blood flow accelerated, increased blood flow; hepatic artery - portal vein fistula, right hepatic vein branch and left hepatic vein branch traffic branch formation. Intermittent block group of liver damage lighter but long-lasting, blocking the right hepatic lobule swelling, relax and improve; 6 weeks after the left lobe slightly increased, the right lobe was not significantly reduced; blocking period PVP, portal vein, hepatic artery blood flow Speed, blood flow changes and ligation group similar intermittent recovery; no vascular fistula formation. CONCLUSIONS: Right ventricular atrophy is caused by sutured RHV in cirrhotic patients, and compensatory hyperplasia of the left lobe is more obvious than intermittent occlusion group. Sutured RHV is more obvious in the early stage of liver damage and can be recovered by itself. Light but lasting; Sutured RHV hemodynamic effects of the more obvious, the liver within the collateral circulation more perfect.