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2-甲氧基雌二醇(2ME2)为雌二醇在体内的生理代谢产物,具有广泛的抗肿瘤作用,是一种具有应用前景的新抗肿瘤药物。其作用机制主要为抑制肿瘤细胞增生、诱导肿瘤细胞凋亡及抗肿瘤血管形成。体内外实验表明:2ME2能抑制神经胶质瘤细胞的增殖,提高载瘤动物的生存期。本文就2ME2的抗肿瘤作用及相关机制研究进行综述。
2-Methoxyestradiol (2ME2) is a physiological metabolite of estradiol in the body and has a wide range of anti-tumor effects. It is a promising antitumor drug. The main mechanism of action is to inhibit tumor cell proliferation, induce tumor cell apoptosis and anti-tumor angiogenesis. In vitro and in vivo experiments show that: 2ME2 can inhibit the proliferation of glioma cells and improve the survival of tumor-bearing animals. This article reviews the anti-tumor effect of 2ME2 and its related mechanisms.