染色体畸变和肿瘤的关系密切,已为人们所熟知。1956年Levan等首先在肺癌胸水细胞中发现所有的细胞内均有标记的环状染色体。翌年,他们进一步观察,认为肺癌细胞染色体数是75,超过140个染色体者占10％。10年后Jackson等在7例肺癌患者胸水细胞染色体的核型分析中,发现其中6例为非正倍体或多倍体,仅1例为二倍体。以后陆续有相类似的报道发表。在国内, Chromosome aberrations are closely related to tumors and are well known. In 1956, Levan et al. first discovered that all cells had labeled circular chromosomes in lung cancer pleural effusion cells. In the following year, they further observed that the number of chromosomes in lung cancer cells is 75, and 10% of those with more than 140 chromosomes. Ten years later, Jackson et al. in the karyotype analysis of pleural effusion cells in 7 lung cancer patients found that 6 of them were non-orthoploid or polyploid and only 1 was diploid. Later, similar reports were published one after another. domestic,