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急性非淋巴细胞白血病对(acute non-lymphocyticleukemia,ANLL)是和恶性病治疗有关的并发症,常继发于淋巴瘤化疗后,而继发于小细胞肺癌则较少。作者对377例治疗后的小细胞肺癌作随访研究,发现有2例发生 ANLL。377例小细胞肺癌中,男283、女94例,年龄29～82(平均59.5)岁,均经组织学或细胞学检查确诊。全部病例均曾接受联合化疗,所用药物包括环磷酰胺、阿霉素、长春新碱,部分病例加鬼臼素、氨甲蝶呤和/或六甲密胺。部分病例仪接受长春新碱治疗1疗程,用药剂量为:环磷酰胺1000mg/M~2,阿霉素
Acute non-lymphocytic leukemia (ANLL) is a complication associated with the treatment of malignant disease, often secondary to lymphoma after chemotherapy, and secondary to small-cell lung cancer is less. The authors of 377 cases of small cell lung cancer after follow-up study found that 2 cases of ANLL. Of the 377 small cell lung cancers, 283 were males and 94 were females, ranging in age from 29 to 82 (mean, 59.5) years of age and were confirmed by histology or cytology. All the patients had received combined chemotherapy. The drugs used included cyclophosphamide, doxorubicin, vincristine, some cases plus podophyllotoxin, methotrexate and / or hexamethamine. Some cases received vincristine treatment of a course of treatment, the dose was: cyclophosphamide 1000mg / M ~ 2, doxorubicin