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美托洛尔（MP）为一种R；受体阻滞剂，是治疗轻中度高血压和顽固性心绞痛的首选药物。但因口服后对肝脏首过效应十分敏感，其生物半衰期短。透皮给药能避免肝脏首过效应，提高药物的全身生物利用度。本文报道MP经探鼠口服和透皮给药后的生物利用度，同时考察MP对裸鼠的皮肤刺激
Metoprolol (MP) is a R-receptor blocker that is the drug of choice for the treatment of mild to moderate hypertension and refractory angina. However, after oral administration of the liver is very sensitive to the first pass, the biological half-life short. Transdermal administration can avoid the first pass effect of the liver and improve the systemic bioavailability of the drug. This article reports the bioavailability of MP after oral administration and transdermal administration of MP and explores the effect of MP on skin irritation in nude mice