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目的探讨癌细胞胞质桥粒及其形成的机制和意义。方法应用透射电子显微镜观察人体卵巢癌细胞、外阴癌细胞、子宫内膜癌细胞和子宫颈癌细胞的超微结构。结果发现这些癌细胞不仅有表面的桥粒，而且都有胞质桥粒。大多数胞质桥粒存在于胞膜内面或核膜外周附近的胞质内，有形成完好的，也有正在形成中的。胞质桥粒周围见有较多的多聚核糖体、张力微丝和粗面内质网。结论胞质桥粒广泛存在于人体卵巢癌细胞、外阴癌细胞、子宫内膜癌细胞和子宫颈癌细胞。我们推测胞质桥粒的形成是在癌细胞完全分裂之后根据细胞自身机能的需要而产生的。
Objective To explore the mechanism and significance of cytoplasmic desmosomes and their formation in cancer cells. Methods Transmission electron microscopy was used to observe the ultrastructure of human ovarian cancer cells, vulvar cancer cells, endometrial cancer cells and cervical cancer cells. As a result, it was found that these cancer cells not only have surface desmosomes but also have cytoplasmic desmosomes. Most cytoplasmic desmosomes exist in the cytoplasm or in the cytoplasm near the outer periphery of the nuclear membrane, and they are well formed and are still being formed. There are more polyribosomes, tension microfilaments, and rough endoplasmic reticulum around cytoplasmic desmosomes. Conclusion Cytoplasmic desmosomes are widely present in human ovarian cancer cells, vulvar cancer cells, endometrial cancer cells and cervical cancer cells. We speculate that the formation of cytoplasmic desmosomes is based on the needs of the cell’s own functions after the cancer cells have completely divided.