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最近由美国和意大利神经科学家合作进行的一项研究揭示了吗啡引发小鼠急性热痛觉过敏的通信号转导通路。他们给小鼠皮下注射极低剂量(1~10μg/kg)的吗啡,在热板测试中诱发痛觉过敏反应,然后检验这种低剂量吗啡所引起的急性痛敏现象是否与阿片受体介导的PLC/PKC肌醇-磷脂信号转?
A recent study by U.S. and Italian neuroscientists revealed a signaling pathway that leads to morphine-induced acute thermal hyperalgesia in mice. They injected mice with a very low dose of morphine (1 to 10 μg / kg) subcutaneously to induce hyperalgesia in hot-plate tests and then examined whether acute pain-induced effects of this low-dose morphine were mediated by opioid receptors Of PLC / PKC Inositol - Phospholipid Signaling?