目的　以昆明小鼠作实验动物模型 ,探讨猪囊虫病基因工程疫苗的免疫效果。方法　 78只昆明小鼠随机分为 3组 ,第一组用猪囊虫病基因工程疫苗免疫 1次 ,每二组免疫 2次 ,第三组不免疫。第一次免疫后 2 0 d各小鼠经尾静脉感染已孵化的有活力的六钩蚴 ,6 3d后剖检小鼠检查有无囊虫 ,并观察虫体的活力。用免疫学方法检测血清中囊虫抗原和抗体 ,以监测疫苗的免疫反应及虫体寄生状况。结果　所有免疫小鼠均未出现不良反应 ;免疫 7d后部分免疫小鼠可检测到囊虫抗体 ,免疫后2 1d所有免疫小鼠的囊虫抗体均呈阳性。未免疫的第三组各小鼠均检出囊虫 ,共 6 5个 ,主要寄生在胸腔 ;第一组和第二组分别有 2只和 1只小鼠检出囊虫 ,分别为 2个和 1个 ,保护率分别为 96 .9%和 98.4%。CA检测结果与剖检结果一致 ,检出囊虫的小鼠 ,其 CA均呈阳性。结论　用小鼠动物模型可进行猪囊虫病免疫预防试验 ,猪囊虫病基因工程疫苗安全性好 ,免疫效力高 Objective To study the immune effect of genetic engineering vaccine of swine cysticercosis with Kunming mice as experimental animal model. Methods Totally 78 Kunming mice were randomly divided into 3 groups. The first group was immunized with genetic engineering vaccine of swine cysticercosis once, twice in every two groups, and the third group was not immunized. At 20 days after the first immunization, the mice were infected via the caudal vein with viable Echinococcus granulosus. After 6 days, the mice were examined for the presence of cysticercosis and the viability of the parasites was observed. Serum cysticercosis antigens and antibodies were detected by immunological methods to monitor the immune response and parasite status of the vaccine. Results All immunized mice showed no adverse reactions. After 7 days of immunization, the immunized mice could detect cysticercus antibodies, and the immunized mice showed positive cysticercosis antibodies on day 21 after immunization. A total of 65 cysticerci were detected in the non-immunized third group of mice, mainly in the thoracic cavity. Two cysts and one mouse were detected in the first group and the second group, respectively And one, the protection rates were 96.9% and 98.4% respectively. CA test results consistent with the results of the autopsy, cysticercosis in mice, the CA was positive. Conclusion The animal model of swine can be used for the immunoprophylactic test of swine cysticercosis. The genetic engineering vaccine for swine cysticercosis is safe and has high immunogenicity