B淋巴细胞分化成浆细胞是一个抗原介导的过程,主要依赖于B细胞和调控因子在它们的微环境中的相互作用。寿命长的浆细胞来自于生发中心活化的B细胞,而浆细胞分化自滤泡外区的幼稚B细胞,其寿命短。因此,来自于后生发中心的淋巴瘤常呈浆细胞分化,而来自于幼稚B细胞的淋巴瘤则很少 Differentiation of B lymphocytes into plasma cells is an antigen-mediated process that relies primarily on the interaction of B cells and regulatory elements in their microenvironment. Plasma cells with long lifespan come from activated B cells in the germinal center, whereas plasma cells differentiate from naive B cells in the extracorporeal follicle and have short lifespans. Thus, lymphomas from the germinal center often have plasmacytoid differentiation, whereas lymphoma from naive B-cells is rare