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作者应用特异性胃动素抗体,通过放射免疫测定法,测定了妊娠高血压综合征(妊高征)患者50例和正常晚期妊娠妇女40例血浆胃动素的含量.结果表明:轻度妊高征患者血浆胃动素含量(124.00±22.00)ng/L)与正常晚期孕妇相差不大(121.12±27.00 ng/L);中度妊高征者血浆胃动素含量(140.00±17.21ng/L)较正常晚期孕妇高,但无统计学差异(P>0.05);重度妊高征患者血浆胃动素含量(16640±18.91 ng/L)明显高于正常晚期孕妇(P<0.01).在重度妊高征中,合并有肝、肾功能损害者,血浆胃动素含量(194.12±20.05 ng/L)明显高于无肝、肾功能损害者(140.17±28.00ng/L)(P<0.01).作者认为,妊高征患者血浆胃动素浓度增高,可能与迷走神经张力增加、肝脏灭活减少、肾脏滤过障碍及性激素水平相对下降有关.
The authors used specific motilin antibodies to determine plasma motilin levels in 50 patients with gestational hypertension (PIH) and 40 normal pregnant women by radioimmunoassay.The results showed that: mild pregnancy The level of plasma motilin in patients with hypertension (124.00 ± 22.00 ng / L) was similar to that of normal pregnant women (121.12 ± 27.00 ng / L) L) was higher than that of normal pregnant women (P> 0.05). The level of plasma motilin in patients with severe PIH (16640 ± 18.91 ng / L) was significantly higher than that of normal pregnant women (P <0.01) Among the patients with severe PIH, the levels of plasma motilin (194.12 ± 20.05 ng / L) were significantly higher than those without liver and renal dysfunction (140.17 ± 28.00 ng / L) (P <0.01). The authors believe that patients with PIH plasma concentration of motilin increased, may be associated with increased vagal tone, decreased liver inactivation, renal filtration disorders and the relative decline in sex hormone levels.