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本文测定了45例难治性肾病综合征(refracto- ry nephropathy syndrome,RNS)患者冲击治 疗前后血清、尿中肿瘤坏死因子(TNF_α)的水平,试 图从细胞因子水平观察四联双冲击疗法对RNS的 效果。 材料和方法 一、病例选择:45例(男24,女21),均系我院确诊 的住院患者,年龄15～53岁。在使用本疗法之前,患 者均已经接受过皮质激素、环磷酰胺治疗,尿蛋白未 见明显减少,并有反复发作者。 二、治疗:以蛇毒抗栓酶、地塞米松、环磷酰胺辅 以中药按方案治疗。 三、血清尿中TNF_α测定:分别于治疗前及治疗 一疗程后采血,分离血清,留晨尿-20℃保存。TNF 试剂盒由东亚免疫技术研究所提供,操作按说明 书。 结果 一、45例RNS患者治疗前后临床特点及有关生 化指标的变化见表1。
In this paper, the levels of TNF-α in serum and urine of 45 patients with refractory nephropathy syndrome (RNS) before and after impact therapy were measured in an attempt to observe the effect of quadruplex shock therapy on RNS Effect. Materials and methods First, the choice of cases: 45 cases (male 24, female 21), all confirmed hospitalized patients in our hospital, aged 15 to 53 years. Before using this therapy, patients had received corticosteroids, cyclophosphamide treatment, urinary protein was not significantly reduced, and repeated attacks. Second, treatment: snake venom antithrombotic enzyme, dexamethasone, cyclophosphamide supplemented by traditional Chinese medicine treatment according to the program. Third, serum TNF_α determination: respectively, before treatment and after treatment of a course of blood collection, separation of serum, leaving morning urine -20 ℃ preservation. TNF kit provided by the East Asian Institute of Immunization Technology, according to the instructions. Results A 45 cases of RNS patients before and after treatment of clinical features and changes in biochemical indicators in Table 1.