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目的:比较雷公藤多苷片(TG)及环磷酰胺(CTX)治疗肾病综合征的疗效(显效率、总有效率),为临床应用雷公藤多苷片治疗肾病综合征提供指导。方法:按系统评价的要求,以雷公藤多苷/环磷酰胺/糖皮质激素/肾病综合征(中英文)为检索词,在1979年—2011年在国内公开发表的中英文文献,统一纳入标准和排除标准,所得文献进行Meta分析。结果:雷公藤多苷片联合泼尼松治疗肾病综合征的显效率(OR=1.00,95%CI为0.57～1.75)和总有效率(OR=0.87,95%CI为0.41～1.85)与CTX联合泼尼松的疗效没有显著性差异。显效率、总有效率、复发率“漏斗图”图形基本对称。结论:雷公藤多苷片联合泼尼松与CTX联合泼尼松治疗肾病综合征的疗效相当。
OBJECTIVE: To compare the efficacy (significant efficiency and total effective rate) of TWP and CTX in the treatment of nephrotic syndrome and provide guidance for the clinical application of TWP in treating nephrotic syndrome. METHODS: According to the requirements of systematic reviews, the Chinese and English literature published in China from 1979 to 2011 were taken as the search terms with the terms of tripterygium glycosides / cyclophosphamide / glucocorticoid / nephrotic syndrome (Chinese and English) Standards and exclusion criteria, the resulting literature Meta-analysis. Results: Significant efficiency (OR = 1.00, 95% CI 0.57 ~ 1.75) and total effective rate (OR = 0.87, 95% CI 0.41 ~ 1.85) The efficacy of combined prednisone did not differ significantly. Significant efficiency, total efficiency, recurrence rate “Funnel ” graphics basic symmetry. CONCLUSION: Tripterygium glycosides tablets combined with prednisone and CTX in combination with prednisone have similar efficacy in treating nephrotic syndrome.