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目的 探讨心肌肌钙蛋白Ⅰ (CTn Ⅰ )在新生儿胎粪吸入综合征 (MAS)并心肌损伤诊断中的意义。方法 用化学发光免疫法及酶法分别测定 35例合并心肌损伤的MAS患儿、30例无心肌损伤的MAS患儿及 15例正常对照组血清CTn Ⅰ及CK MB的水平。结果 心肌损伤组生后 2～ 3dCTn Ⅰ浓度为 (0 .6 7± 0 .13)ng/ml,较MAS对照组 [(0 .0 7± 0 .0 5 )ng/ml]和正常对照组 [(0 .0 7± 0 .0 3)ng/ml]明显升高 ,差异有显著性意义 (P <0 .0 5 )。结论 CTn Ⅰ是诊断新生儿MAS并心肌损伤的特异性指标之一。
Objective To investigate the significance of cardiac troponin Ⅰ (CTn Ⅰ) in the diagnosis of neonatal meconium aspiration syndrome (MAS) and myocardial injury. Methods The levels of serum CTn Ⅰ and CK MB in 35 children with MAS with myocardial injury, 30 children without myocardial injury and 15 normal controls were measured by chemiluminescence immunoassay and enzymatic method respectively. Results The level of CTn Ⅰ at 2 ~ 3d after myocardial injury group was (0.67 ± 0.13) ng / ml, significantly higher than that in MAS control group [(0.07 ± 0.05) ng / ml] and normal control group [(0.07 ± 0.03) ng / ml] was significantly increased, the difference was significant (P <0.05). Conclusion CTn Ⅰ is one of the specific indexes for diagnosing neonatal MAS and myocardial injury.