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目的比较拉米夫定和替比夫定治疗妊娠期轻度乙型肝炎病毒感染的疗效及对妊娠结局的影响。方法将妊娠期乙型肝炎孕妇240例随机分为替比夫定组和拉米夫定组各120例。替比夫定组给予替比夫定治疗,拉米夫定组给予拉米夫定治疗。治疗后观察2组患者治疗效果及妊娠结局。结果替比夫定组患者总有效率为94.17%高于拉米夫定组的71.67%,差异有统计学意义(P<0.05)。2组患者剖宫产率、胎膜早破、胎儿窘迫、早产、产后出血、死胎的发生率比较差异均无统计学意义(P>0.05)。结论替比夫定治疗妊娠期轻度乙型肝炎病毒感染的疗效优于拉米夫定,但两者对妊娠结局的影响相近。
Objective To compare the efficacy of lamivudine and telbivudine in the treatment of mild hepatitis B virus infection during pregnancy and its effect on pregnancy outcome. Methods Two hundred and forty pregnant women with hepatitis B during pregnancy were randomly divided into telbivudine group and lamivudine group. Telbivudine group was given telbivudine treatment, lamivudine group was given lamivudine treatment. After treatment, the treatment effect and pregnancy outcome in two groups were observed. Results The total effective rate was 94.17% in telbivudine group and 71.67% in lamivudine group, the difference was statistically significant (P <0.05). There was no significant difference in the incidence of cesarean section, premature rupture of membranes, fetal distress, premature birth, postpartum hemorrhage and stillbirth in both groups (P> 0.05). Conclusion The effect of telbivudine in treatment of mild hepatitis B virus infection during pregnancy is better than that of lamivudine, but the effect of telbivudine on pregnancy outcome is similar.