WDR蛋白家族(Trp-asp repeat protein family)是含有多个保守WD基序(WD motif)的蛋白质类,广泛存在于真核生物中。近年,WDR蛋白的研究已成为细胞生物学和病理学研究的新热点。目前已知多种WDR蛋白在肿瘤细胞中异常表达,并通过调节信号转导、细胞周期、泛素化、转录和RNA加工等生物过程促使肿瘤发生。现对WDR蛋白在肿瘤发生发展中的作用机制作一综述。 The Trp-Asp repeat protein family is a protein that contains several conserved WD motifs and is widely found in eukaryotes. In recent years, the study of WDR protein has become a new hot spot in the research of cell biology and pathology. A variety of WDR proteins are currently known to be aberrantly expressed in tumor cells and to promote tumorigenesis by regulating biological processes such as signal transduction, cell cycle, ubiquitination, transcription and RNA processing. The mechanism of action of WDR protein in tumorigenesis is reviewed.