论文部分内容阅读
目的 临床标本分离细菌时有产诱导型β-内酰胺酶和超广谱β-内酰胺酶的菌株。为给临床提供可靠的药敏数据 ,以达到较好的抗感染效果。方法 按美国临床实验室标准化委员会 ( NCCL S)推荐的指南进行。采用双纸片法测超广谱β-内酰胺酶和诱导型β-内酰胺酶。结果 亚胺培南、环丙沙星、诺氟沙星对 3 4株产诱导型β-内酰胺酶的铜绿假单胞菌的抗菌活性较强。亚胺培南对产超广谱β-内酰胺酶的大肠埃希菌及肺炎克雷伯菌有较强的抗菌活性。结论 产生诱导型β-内酰胺酶和产生超广谱β-内酰胺酶的革兰阴性杆菌为多重耐药菌株。
Objective Isolation of bacteria in clinical specimens producing induced β-lactamase and extended-spectrum β-lactamase strains. In order to provide reliable clinical drug susceptibility data in order to achieve better anti-infective effect. Methods were performed according to guidelines recommended by the National Committee for Clinical Laboratory Standards (NCCL S). Extended-spectrum β-lactamase and inducible β-lactamase were measured by double disc method. RESULTS: Imipenem, ciprofloxacin and norfloxacin showed strong antibacterial activity against 34 strains of Pseudomonas aeruginosa producing inducible β-lactamases. Imipenem on producing extended-spectrum β-lactamase Escherichia coli and Klebsiella pneumoniae have strong antibacterial activity. Conclusions Gram-negative bacilli producing inducible β-lactamases and producing extended-spectrum β-lactamase are multi-drug resistant strains.