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通过测定大鼠尿中γ－谷氨酰转肽酶（γ－ＧＴ）的浓度、测定血中尿素氮（ＢＵＮ）及肌酐（Ｃｒ）的含量、以及大鼠肾脏对氨马尿酸和菊糖清除率，判断环孢素Ａ（ＣｓＡ）对肾小球及肾小管功能的影响以及伊拉地平对ＣｓＡ肾毒性的保护作用。结果显示，ＣｓＡ可使大鼠尿中γ－ＧＴ含量随给药天数的增加而升高，给药７天后，血中ＢＵＮ、Ｃｒ含量均较对照组增高，且肾脏菊糖和对氨马尿酸清除率显著降低，尤以后者降低更为严重。伊拉地平可使上述变化明显减轻。提示，伊拉地平可使ＣｓＡ造成的肾小球及肾小管功能的损害得以改善，ＣｓＡ对肾小球及肾小管的毒性机理可能与缩血管作用有关。钙拮抗剂在防治ＣｓＡ肾毒性中有临床价值。
The concentration of γ-glutamyl transpeptidase (γ-GT) in rat urine was measured to determine the content of blood urea nitrogen (BUN) and creatinine (Cr) Rate, determine the impact of cyclosporin A (CsA) on glomerular and renal tubular function and the protective effect of idaripine on CsA nephrotoxicity. The results showed that CsA could increase the urinary γ-GT content of rats with the increase in the number of days, after 7 days of administration, the levels of BUN and Cr in the blood increased compared with the control group, and the renal inulin and p- Clearance rate significantly reduced, especially in the latter to reduce even more serious. Iraqi peace can significantly reduce these changes. It is suggested that the degradation of glomerular and tubular function caused by CsA can be improved by the intravaginal administration of ilapirtine. The toxic mechanism of CsA to glomerular and tubular may be related to vasoconstriction. Calcium antagonists in the prevention and treatment of CsA nephrotoxicity has clinical value.