关于骨硬化症与机体的关系,已有许多报告,但其原因说法不一。作者试图进一步证实小鼠胸腺退化的资料,并在体外鉴别gL/gL小鼠和同窝对照鼠之间在胸腺非淋巴细胞(TNLC)培养物中的差别。作者使用了GL/Le小鼠,其基因型分别为~+gl/dL~+、~+gl/gL及dL~+/dL~+等;其表现型为+、gL及dL等。gL为灰色致死性小鼠(grey-Lethal)的一种表现型,它常患先天性骨硬化症,一般于40天死亡。表现型为+和dL There have been many reports on the relationship between osteopetrosis and the body, but the reasons are not the same. The authors sought to further substantiate the evidence of thymus degeneration in mice and identify in vitro differences in thymus non-lymphocyte (TNLC) cultures between gL / gL mice and littermate control mice. The authors used GL / Le mice whose genotypes were ~ + gl / dL ~ +, ~ + gl / gL and dL ~ + / dL ~ +, respectively; their phenotypes were +, gL and dL. The gL is a phenotype of gray-lethal mice, which often have congenital osteopetrosis and usually die on the 40th day. Phenotypes were + and dL