论文部分内容阅读
目的:评价国产克拉霉素的临床疗效。方法:选择35例呼吸道和皮肤组织感染患者,其中20例与进口克拉霉素随机对照,15例为开放试验组。剂量均为250mg/次,bid。结果:国产和进口克拉霉素组的有效率分别为95%和90%,细菌清除率分别为94.4%和97.7%。国产克拉霉素开放组15例,有效率为91.4%,细菌清除率为92.3%。两组的不良反应均轻微。体外抗菌活性显示,克拉霉素对金葡菌、β溶血性链球菌和肺炎球菌有较强的抗菌活性。结论:国产与进口克拉霉素的临床疗效和安全性相仿
Objective: To evaluate the clinical efficacy of domestic clarithromycin. Methods: Thirty-five patients with respiratory and skin infections were selected. Twenty patients were randomly assigned to clarithromycin and fifteen were open-label. The dosage is 250mg / time, bid. Results: The effective rates of domestic and imported clarithromycin were 95% and 90% respectively, and the bacterial clearance rates were 94.4% and 97.7% respectively. Domestic clarithromycin open group of 15 cases, the effective rate was 91.4%, the bacterial clearance rate was 92.3%. Adverse reactions were mild in both groups. In vitro antibacterial activity showed that clarithromycin against Staphylococcus aureus, β-hemolytic streptococcus and pneumococcus have strong antibacterial activity. Conclusion: The clinical efficacy and safety of domestic and imported clarithromycin are similar