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目的测定糖尿病周围神经病变(DPN)患者血清内脏脂肪素(Visfatin)水平,探讨Visfatin与DPN的相关性。方法选取我科住院的T2DM患者90例,分为T2DM合并周围神经病变组(DPN)58例,T2DM不合并周围神经病变组(Non-DPN)32例。另选正常对照组(NC)30名。测定各组FPG、TG、TC、LDL-C、HDL-C,Fins、Visfatin及肝、肾功能;稳态模型评估胰岛素抵抗指数(HOMA-IR)、胰岛β细胞功能指数(HOMA-β)。结果 Visfatin水平在NC、Non-DPN和DPN组逐渐升高[(141.3±57.5)vs(242.3±58.0)vs(350.1±59.8)pg/ml](P<0.05)。Visfatin水平与病程、WHR、FPG、HbA_1c、TG、胱抑素C(Cys-C)、UAER呈正相关(r分别为0.323、0.128、0.449、0.325、0.172、0.327、0.329,P<0.05),与HOMA-β呈负相关(r=-0.497,P<0.01);Logistic回归分析显示,Visfatin是影响DPN发生的独立危险因素。结论血清Visfatin水平的升高可能与DPN有关。
Objective To determine the serum visfatin level in patients with diabetic peripheral neuropathy (DPN) and to explore the correlation between Visfatin and DPN. Methods Totally 90 T2DM patients hospitalized in our department were divided into T2DM with peripheral neuropathy (DPN) group (58 cases) and T2DM without peripheral nerve group (Non-DPN) with 32 cases. Another 30 normal control group (NC). The levels of FPG, TG, TC, LDL-C, HDL-C, Fins, Visfatin and hepatic and renal function in each group were determined. HOMA-β and HOMA-β were evaluated by homeostasis model. Results Visfatin levels were gradually increased in NC, Non-DPN and DPN groups (141.3 ± 57.5 vs 242.3 ± 58.0 vs 350.1 ± 59.8 pg / ml, P <0.05). The level of Visfatin was positively correlated with the course of disease, WHR, FPG, HbA 1c, TG, Cystatin C and UAER (r = 0.323,0.128,0.449,0.325,0.172,0.327,0.329, P <0.05) HOMA-β was negatively correlated (r = -0.497, P <0.01). Logistic regression analysis showed that Visfatin was an independent risk factor for DPN. Conclusion The increase of serum Visfatin may be related to DPN.