目的:研究安宫牛黄分散片的制备工艺。方法:对填充剂微晶纤维素(MCCHP101)处方用量进行单因素考察,对崩解剂的用量、种类、粘合剂浓度进行正交试验考察。以分散均匀性、崩解时限、硬度为指标,确定制备工艺。结果:选用0.9%MCCHP101作填充剂,20%交联聚乙烯基吡咯烷酮(PVPP)作崩解剂,5%聚维酮(PVP-k30)溶液适量作粘合剂,效果较佳。结论:该安宫牛黄分散片的制备工艺符合质量标准。 Objective: To study the preparation technology of Angong Bezoar dispersible tablets. Methods: The dosage of microcrystalline cellulose (MCCHP101) was investigated by single factor method. The dosage of disintegrant, the type of binder and the concentration of binder were investigated by orthogonal test. Dispersing uniformity, disintegration time, hardness as an indicator to determine the preparation process. Results: The best effect was obtained by using 0.9% MCCHP101 as filler, 20% cross-linked polyvinylpyrrolidone (PVPP) as disintegrator and 5% PVP-k30 as adhesive. Conclusion: The preparation process of Angong Bezoar dispersible tablets conforms to the quality standard.