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为了观察伊曲康唑治疗甲真菌病各种方法的疗效， 探索服用该药的最低剂量和最佳治疗方案， 应用正交实验法观察了４６ 例服用伊曲康唑的甲真菌病患者。结果显示：在４ 个观察组（１００ｍ ｇ 每日１ 次，连续口服；１００ｍｇ ，每日２ 次，隔周口服；２００ｍ ｇ ，每日１ 次， 隔周口服；２００ｍｇ ， 每日２ 次， 每月服用１ 周）中， 指甲癣治疗时间最短的方法是： ２００ｍｇ 每日１次， 隔周口服（ 平均治愈时间３．１１ 个月） ； 趾甲癣治疗时间最短的是：１００ｍ ｇ ，每日２ 次，隔周口服（ 平均治愈时间３．７０ 个月） 。结论是： 伊曲康唑治疗指、趾甲真菌病的最佳服药方都是１００ｍｇ ，每日１ 次， 隔周口服。大剂量冲击疗法与本实验所观察的其它３ 种方法的疗效无显著差异（ Ｐ ＞ ０．０５） 。在本实验所列举的３ 种影响因素中， 每个疗程的时间间隔是影响疗效的主要因素； 每次服药剂量和每天服药次数对疗效的影响相差不多， 可以认为在相同条件下，１００ｍ ｇ 每日２ 次和２００ｍ ｇ ， 每日１ 次两种服药方法的疗效是相当的。
In order to observe the efficacy of itraconazole in the treatment of onychomycosis, explore the minimum dosage and the best treatment regimen, and observe 46 cases of onychomycosis with itraconazole by orthogonal test. The results showed that: in the four observation groups (100m g once daily, continuous oral; 100mg, twice daily orally every other week; 200m g, once daily, orally every other week; 200mg twice daily Month taking 1 week), the shortest treatment time of nail ringworm was 200mg once daily and oral every other week (the average healing time was 3.11 months); the shortest treatment time of nails ringworm was 100m g daily Times, oral every other week (the average healing time 3.70 months). The conclusion is: the treatment of itraconazole, toenail mycosis best prescription are 100mg, 1 day, every other week oral. There was no significant difference between the high dose shock therapy and the other three methods observed in this experiment (P> 0.05). Among the three kinds of influencing factors listed in this experiment, the interval of each course of treatment is the main factor affecting the curative effect. The effect of each dose and the number of taking medicine on the curative effect is similar. It can be considered that under the same conditions, 2 times a day and 200m g, 1 times a day two kinds of medication efficacy is quite.