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原发性IgA肾病,Henoch-Schonlen紫癜(HSP)或酒精性肝病(ALD)其外观健康皮肤的浅表血管壁有颗粒状IgA沉积这是众所周知的。但由于实验室方法和对标本解释等方面的不同,因而对其诊断价值尚有争论。为此作者研究了肾、肝疾病患者皮肤IgA沉积的特异性,该发现对诊断原发性IgA肾病的敏感为76％,特异性88％,酒精性肝病的敏感性为71％,但特异性仅60％HSP、原发性IgA碱病或ALD的特异性为94％,免疫电镜检查示IgA沉积限于内皮细胞和内皮下缘。
Primary IgA nephropathy, Henoch-Schonlen purpura (HSP) or alcoholic liver disease (ALD) It is well known that superficial blood vessel walls of healthy skin have granular IgA deposits. However, due to the differences in laboratory methods and specimen interpretation, there is still debate about the diagnostic value. To this end, the authors studied the specificity of IgA deposition on the skin of patients with kidney and liver disease. The findings were 76% sensitive and 88% specific for the diagnosis of primary IgA nephropathy and 71% for alcoholic liver disease, but the specificity Only 60% of HSPs, 94% of patients with primary IgA alkalosis or ALD were identified by immunoelectron microscopy as IgA deposition confined to endothelial cells and the inferior endothelium.