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目的 :比较单药及联合吸入支气管扩张剂 ,对慢性阻塞性肺疾病 (COPD)的疗效。方法 :A、B、C 3组患者分别吸入沙丁胺醇、溴化异丙托品及复合制剂。测定各时段第一秒时间肺活量 (FEV1)、5 0 %肺活量最大呼气流量 ( ·V50 )及其改善率和动脉血氧分压 (PaO2 )。结果 :A组 10分钟见效 ,3 0～ 60分钟达高峰 ;180分钟后降到用药前水平 ;B组 60分钟见效 ,180分钟达高峰 ,3 60分钟降到治疗前水平 ,改善率无差异 ;C组 10分钟见效 ,60～ 180分钟达高峰 ,3 60分钟时仍有显著差异。结论 :单药吸入可改善通气功能 ,但改善率无差异 ;联合吸入见效快、维持时间长 ,优于单药吸入。
OBJECTIVE: To compare the efficacy of bronchodilators and bronchodilators in patients with chronic obstructive pulmonary disease (COPD). Methods: Patients in group A, B and C were treated with albuterol, ipratropium bromide and combination therapy respectively. The vital capacity (FEV1), maximal expiratory flow volume (V˙50) of 50% and its improvement rate and PaO2 were measured in the first second of each time period. Results: Group A was effective at 10 minutes and peaked at 30-60 minutes; it dropped to the level before medication after 180 minutes; Group B was effective at 60 minutes, peaked at 180 minutes, and dropped to pre-treatment level at 3 60 minutes, with no difference in improvement rate; C group 10 minutes effective, peak 60 ~ 180 minutes, 3 60 minutes there are still significant differences. Conclusion: The inhalation of monotherapy can improve the ventilation function, but there is no difference in the rate of improvement. The combined inhalation is effective and sustained for a long time, which is better than single inhalation.