论文部分内容阅读
苯丁酸氮芥常作为免疫抑制剂用于治疗类风湿性关节炎、幼年型慢性关节炎并发淀粉样变、白塞氏综合征的葡萄膜炎和红斑狼疮。但随着药物使用增加,在成人和儿童中的白血病的发病率也增高。1979年国际癌肿研究委员会会议上指出,此药对人类“可能是致癌的”。作者对10例白塞氏综合征伴眼葡萄膜炎用苯丁酸氮芥治疗的患者进行了观察。治疗组男、女各5例,年龄22～42岁。用药剂量为每天2～6mg,持续治疗期为0.3～68个月。同时选15名健康人和10例不用苯
Chlorambucil is often used as an immunosuppressive agent for the treatment of rheumatoid arthritis, juvenile chronic arthritis complicated by amyloidosis, Behcet’s syndrome uveitis and lupus erythematosus. However, as drug use increases, the incidence of leukemia in adults and children also increases. 1979 International Cancer Research Council meeting pointed out that the drug on human beings may be “carcinogenic.” The authors of 10 cases of Behcet’s syndrome with uveitis were treated with chlorambucil in patients were observed. Treatment group, male and female in 5 cases, aged 22 to 42 years. Dosage per day 2 ~ 6mg, continuous treatment period of 0.3 to 68 months. At the same time choose 15 healthy people and 10 cases without benzene