软组织肉瘤构成儿童大部分恶性间叶肿瘤,其中以横纹肌肉瘤为最常见,发病年龄通常在21岁以下。但是,恶性纤维组织细胞瘤(MFH)则常见于成年以后,多见于手、足、腹膜后或肾盂。有关儿童的MFH,已发表的资料很少,又因少见,故在儿科领域内的发展及治疗尚不清楚。美国费城儿童医院癌症研究中心,于1975年1月至1983年7月收治121名患有躯体软组织恶性肿瘤的儿童。7例为MFH,患儿在诊断时年龄为6月至11岁(平均3岁),均为男性,其中5例白人,2例黑人。 Soft tissue sarcomas constitute the majority of malignant mesenchymal tumors in children, of which rhabdomyosarcoma is the most common, the onset of age is usually less than 21 years of age. However, malignant fibrous histiocytoma (MFH) is common in adults, more common in hand, foot, retroperitoneal or renal pelvis. The published data on children’s MFH are rare and rare. Therefore, the development and treatment in the pediatric field are not yet clear. Philadelphia Children’s Hospital Cancer Research Center, Philadelphia, USA, from January 1975 to July 1983, 121 children with somatic and soft tissue malignancies were treated. Seven patients were MFH, and children at diagnosis were between 6 and 11 years of age (mean, 3 years), all of whom were male, of whom 5 were white and 2 were black.