目的观察小剂量红霉素治疗极低出生体重早产儿喂养不耐受的效果。方法将我科2000年2月至2011年2月间收治的极低出生体重早产儿喂养不耐受患儿60例,按就诊先后随机分为治疗组和对照组各30例,对照组在常规治疗的基础上采取体位疗法,治疗组在对照组的基础上加用小剂量红霉素3～5mg/(kg·d),加入5%或10%葡萄糖中静脉点滴,浓度1mg/ml,每次维持1～2h,分1～2次给予,至患儿喂养耐受后2～3d,5～7d为一疗程。结果治疗组显效12例,有效10例,无效8例,显效率40%,总有效率73.3%;对照组显效3例,有效4例,无效23例,显效率10%,总有效率23.3%。两组显效率及总有效率差异具有统计学意义(P<0.01),治疗组优于对照组。结论小剂量红霉素治疗极低出生体重早产儿效果明显,且安全,值得推广使用。 Objective To observe the effect of low dose erythromycin in treating intolerance in very low birth weight premature infants. Methods 60 cases of infants with very low birth weight who were admitted to our department between February 2000 and February 2011 were randomly divided into treatment group and control group, On the basis of treatment, body position therapy was used. The treatment group was treated with low dose of erythromycin 3 ~ 5mg / (kg · d) on the basis of the control group, 5% or 10% glucose in the intravenous drip, concentration 1mg / Time to maintain 1 ~ 2h, divided into 1 or 2 times to give the child after feeding tolerance 2 ~ 3d, 5 ~ 7d for a course of treatment. Results In the treatment group, 12 cases were markedly effective, 10 cases were effective, 8 cases were ineffective, the effective rate was 40% and the total effective rate was 73.3%. In the control group, 3 cases were markedly effective, 4 cases were effective and 23 cases were ineffective. The effective rate was 10% and the total effective rate was 23.3% . The difference between the two groups was statistically significant (P <0.01), the treatment group was better than the control group. Conclusion Low dose of erythromycin is effective in treating very low birth weight preterm infants and is safe and worthy of promotion.