多器官功能衰竭(MOF)危重病人的氧自由基清除系统障碍和氧化剂压力(oxidant stress)的增大直接涉及组织损伤,另外一些潜在因素也与细胞内、外氧化剂压力的增强有关,例如吸高浓度氧以期提高动脉血氧饱和度、激活中性白细胞、全身感染以及使用了原氧化剂(pro-oxidant)等。这些均可能促使活性氧族(reactire oxygen species;ROS)蓄积和抗氧化因子消耗。在ICU内病人微循环灌注中,由于缺血再灌注损伤而产生ROS。 现已证实各类肾脏疾病尤其是中毒性或缺血性肾衰,ROS在发病机制中起重要作用,而缺乏抗氧化因子则加重肾损伤。如果在肾缺血或肾中毒之前使用抗氧化剂,可通过清除氧自由基从而阻止或减轻肾损害。在肾移植之前,给病人使用多种维生素往往能减少移植肾之后并发急性肾衰 Multiple organ failure (MOF) critically ill patients with oxygen free radical scavenging system and oxidant stress (oxidant stress) increases directly involved in tissue damage, while other potential factors and intracellular and external oxidant pressure increases, such as high Concentration of oxygen in order to improve arterial oxygen saturation, activation of neutrophils, systemic infection and the use of pro-oxidant (pro-oxidant) and so on. These may all contribute to the accumulation of reactive oxygen species (ROS) and depletion of antioxidant factors. In microcirculatory perfusion of patients in the ICU, ROS is produced due to ischemia-reperfusion injury. Has been confirmed that all kinds of kidney disease, especially toxic or ischemic renal failure, ROS plays an important role in the pathogenesis, and the lack of anti-oxidants exacerbate renal damage. If antioxidants are used prior to renal ischemia or nephrotoxicity, kidney damage can be prevented or alleviated by scavenging oxygen free radicals. Prior to kidney transplantation, the use of multivitamins for patients often reduces the incidence of acute renal failure after transplant