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Ibopamine(SB 7505)是一种口服有效的类似多巴胺的药,具有增强肌肉收缩力和血管舒张的作用。在组织和体液中很快被分解成游离的去氧肾上腺素(epinine),游离的去氧肾上腺素是该药药理作用的一部分。试管与体内的研究表明,ibopamine可兴奋多巴胺受体、β-肾上腺素能受体,较高浓度时兴奋α-肾上腺素能受体。在兔的结膜囊内滴药,可使其瞳孔扩大。0.5～4%的溶液滴入人眼,散瞳效应取决于药物剂量。由于没有睫状肌麻痹作用,也没有局部和全身的副作用,所以在诊断方面非常有用。它不引起正常人眼
Ibopamine (SB 7505) is an orally active, dopamine-like drug with an effect of enhancing muscle contractility and vasodilation. It is quickly broken down into tissues and body fluids into free epinine, a free phenylephrine that is part of the pharmacological action of the drug. In vitro and in vivo studies have shown that ibopamine excitates dopamine receptors, beta-adrenergic receptors, and excites alpha-adrenergic receptors at higher concentrations. Drop in the rabbit’s conjunctival sac can make its pupil to expand. 0.5 ~ 4% solution drops into the human eye, the effect of mydriasis depends on the dose of the drug. Because there is no cycloplegia and no local or systemic side effects, it is very useful in the diagnosis. It does not cause normal eyes