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通过兔心肌缺血模型,观察心肌缺血时多项生化指标、组织学变化及Felodipine对缺血性心肌的影响。结果:兔心肌缺血0.5h时,心肌丙二醛、钙、中性粒细胞浸润数及组织含水量均明显升高,而超氧化物歧化酶、Na ̄+-K ̄+-ATPase和Ca ̄(2+),Mg ̄(2+)-ATPase活性明显下降。用Felodipine治疗,上述改变明显减轻,心肌超微结构变化改善,且对心率、血压无明显影响。提示上述诸因素共同参与了心肌缺血性损伤,Felodipine对心肌损伤有明显的保护作用。
Through myocardial ischemia model in rabbits, a number of biochemical indexes, histological changes and the effect of Felodipine on ischemic myocardium were observed. Results: The myocardial malondialdehyde, calcium, neutrophil infiltration numbers and tissue water content were significantly increased at 0.5h after myocardial ischemia in rabbits, but superoxide dismutase, Na ~ + -K ~ + -ATPase and The activities of Ca ~ (2 +) and Mg ~ (2 +) - ATPase decreased obviously. Felodipine treatment, the change was significantly reduced myocardial ultrastructure changes improved, and the heart rate, blood pressure no significant effect. It is suggested that these factors participate in myocardial ischemic injury, Felodipine has a significant protective effect on myocardial injury.