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目的观察使用干扰素治疗丙型肝炎病毒(HCV)合并人类免疫缺陷病毒(HIV)感染患者的眼底特征变化。方法对广州市第八人民医院2009年1月至2014年12月之间收治的69例HCV合并HIV患者,进行全身检查和专科眼部检查。69例患者全部应用聚乙二醇干扰素(Peg-INF)皮下注射治疗,180μg/次,1次/周。结果 HCV合并HIV感染患者皮下注射Peg-INF-α-2a 24周以上后,CD4+T淋巴细胞计数为(328±98)个/μl,显著低于使用干扰素前(410±102)个/μl,差异有统计学意义(P<0.05)。血细胞计数主要表现为白细胞(WBC)和血小板(Plt)计数下降(P<0.05)。眼底出现棉绒斑11例20只眼(占患病例数15.9%),线状出血7例10只眼(占患病例数10.1%),火焰状出血3例5只眼(占患病例数4.3%),棉绒斑合并出血4例(占患病例数5.8%)。结论干扰素可以引起HIV合并HCV患者眼底改变,临床上要定期复查。
Objective To observe the changes of fundus characteristics in patients treated with interferon for hepatitis C virus (HCV) and human immunodeficiency virus (HIV) infection. Methods A total of 69 HCV patients with HCV infection admitted to the Eighth People’s Hospital of Guangzhou from January 2009 to December 2014 were enrolled in this study. All 69 patients were treated with peginterferon (Peg-INF) subcutaneously, 180μg / time, once a week. Results CD4 + T lymphocyte counts (328 ± 98) / μl after Peg-INF-α-2a were injected subcutaneously in HCV-infected HIV-infected patients over 24 weeks were significantly lower than those before IFN-α treatment (410 ± 102) μl, the difference was statistically significant (P <0.05). Blood counts mainly showed a decrease in counts of white blood cells (WBC) and platelets (P <0.05). There were 11 eyes of cotton fleece with 20 eyes (accounting for 15.9%), 7 eyes with linear hemorrhage (10 eyes), 3 cases with flaming hemorrhage (5 eyes) 4.3%), 4 cases of cotton linter with bleeding (5.8%). Conclusion Interferon can cause fundus changes of HIV patients with HCV and should be reviewed regularly.