Objective: To determine if an emergency department- based asthma follow- up clinic could improve outcomes within a high- morbidity pediatric population. Design: Prospective, randomized clinical trial with 6 months of follow- up. Setting: Emergency department of an urban pediatric medical center. Participants: Convenience sample of 488 patients aged 12 months to 17 years, inclusive, with prior physician- diagnos- ed asthma and 1 or more other unscheduled visits in the previous 6 months and/or 1 or more hospitalizations in the prior 12 months. Intervention: Single follow- up clinic visit focusing on 3 domains: asthma self- monitoring and management, environmental modification and trigger control, and linkages and referrals to ongoing care. Main Outcome Measures: The primary outcome measurewas unscheduled visits for acute asthma care. Secondary outcomes included compliance with a medical plan and asthma quality of life. Analysis was by intention to treat with adjustment for baseline differences. Results: Of those randomized to the clinic visit,172 (70.5% ) of 244 attended. The intervention group had significantly fewer mean unscheduled visits for asthma care during follow- up (1.39 vs 2.34; relative risk [RR]=0.60[95% confidence interval (CI), 0.46- 0.77]). At 6 months, significantly more patients in the intervention group reported use of inhaled corticosteroids in the prior 2 days (49.3% vs 26.5% ;RR=2.03 [95% CI, 1.57- 2.62]), no limitation in daytime quality of life (43.8% vs 34.4% ; RR=1.36 [95% CI, 1.06- 1.73]), and no functional limitations in quality of life (49.8% vs 40.8% ; RR=1.33 [95% CI, 1.08- 1.63]). Conclusion: Attendance in the follow- up clinic was high. The intervention decreased subsequent unscheduled health care use while improving compliance and quality of life. Objective: To determine if an emergency department-based asthma follow-up clinic could improve outcomes within a high- morbidity pediatric population. Design: Prospective, randomized clinical trial with 6 months of follow-up. Participants: Convenience sample of 488 patients aged 12 months to 17 years, inclusive, with prior physician- diagnosed asthma and 1 or more other unscheduled visits in the previous 6 months and / or 1 or more hospitalizations in the prior 12 months Intervention: Single follow-up clinic visit focusing on 3 domains: asthma self- monitoring and management, environmental modification and trigger control, and linkages and referrals to ongoing care. Main Outcome Measures: The primary outcome measurewas unscheduled visits for acute asthma care. Secondary outcomes included compliance with a medical plan and asthma quality of life. Analysis was by intention to treat with adjustment for baseline diffe The intervention group had significant fewer unscheduled visits for asthma care during follow-up (1.39 vs 2.34; relative risk [RR] = 0.60 [ 95% confidence interval (CI), 0.46- 0.77]). At 6 months, significantly more patients in the intervention group reported use of inhaled corticosteroids in the prior 2 days (49.3% vs 26.5%; RR = 2.03 [ 1.57-2.62), no limitation in daytime quality of life (43.8% vs 34.4%; RR = 1.36 [95% CI, 1.06-1.73]) and no functional limitations in quality of life = 1.33 [95% CI, 1.08-1.63]). Conclusion: Attendance in the follow-up clinic was high. The intervention decreased subsequent unscheduled health care use while improving compliance and quality of life.