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目的：研究１４ 种抗菌药物对医院内感染常见致病菌－ 铜绿假单胞菌的抗生素后效应（ＰＡＥ） 。方法：采用ＡＶＡＮＴＡＧＥ微生物分析仪的吸光度法测定ＰＡＥ。结果：碳青霉烯类对铜绿假单胞菌的抗菌作用较强，ＰＡＥ较长；氟喹诺酮类抗菌药物的ＰＡＥ很长，可达２ ～４ ｈ，呈显著的浓度依赖性；氨基糖苷类对铜绿假单胞菌有一定的ＰＡＥ，而青霉素类、头孢菌素类和磷霉素对铜绿假单胞菌ＰＡＥ则较短。结论：碳青霉烯类、氟喹诺酮类和氨基糖苷类对铜绿假单胞菌的ＰＡＥ较长，临床在设计给药方案时应重视ＰＡＥ因素。
Objective: To study the antibiotic effect (PAE) of 14 kinds of antibacterials on Pseudomonas aeruginosa, a common pathogen in hospital. Methods: The PAE was determined by the absorbance method of AVANTAGE microbial analyzer. Results: The antibacterial activity of carbapenems against Pseudomonas aeruginosa was stronger and the PAE was longer. The PAE of fluoroquinolone antibacterials was very long, reaching 2-4 h in a concentration-dependent manner. Aminoglycosides Pseudomonas aeruginosa has a certain PAE, while penicillins, cephalosporins and fosfomycin Pseudomonas aeruginosa PAE is shorter. Conclusion: The PAE of carbapenems, fluoroquinolones and aminoglycosides is longer for Pseudomonas aeruginosa. PAE should be paid more attention in the design of drug delivery regimen.