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目的:观察根除幽门螺杆菌(Hp)治疗对消化性溃疡患者食管下括约肌平均压力(LESP)以及长度(LESL)的影响。方法:共观察80例经快速尿素酶法、Giemsa染色、14C呼气试验检测诊断为Hp感染的消化性溃疡患者,Medtronic Esophageal Manometry System检测LESP及LESL。以奥美拉唑肠溶片、克拉霉素缓释片及阿莫西林胶囊3联治疗,疗程5周。观察根除Hp治疗后消化性溃疡患者LESP及LESL的改变。结果:疗程结束,停药1个月后复查,Hp阴性者54例,阳性者26例,Hp根除率为67.5%(54/80)。治疗前LESP(4.21±0.85)kPa,LESL(3.4±1.28)cm,治疗后Hp阴性者LESP(4.16±0.83)(kPa),LESL(3.5±1.32)cm,而Hp阳性者LESP(4.33±0.77)kPa,LESL(3.2±1.36)cm,治疗前与治疗后对比差异均无统计学意义(均P>0.05)。结论:根除Hp治疗对消化性溃疡患者食管动力学无明显影响。
Objective: To observe the effects of Helicobacter pylori eradication (Hp) on the average pressure of lower esophageal sphincter (LESP) and length (LESL) in patients with peptic ulcer. Methods: Eighty patients with peptic ulcer diagnosed as Hp infection by rapid urease, Giemsa staining and 14C breath test were observed. LESP and LESL were detected by Medtronic Esophageal Manometry System. To omeprazole enteric-coated tablets, clarithromycin sustained-release tablets and amoxicillin capsules triple therapy for 5 weeks. To observe the changes of LESP and LESL in peptic ulcer patients after Hp eradication. Results: At the end of the course of treatment, 1 month after discontinuation, 54 were Hp negative and 26 were positive. The Hp eradication rate was 67.5% (54/80). LESP (4.16 ± 0.83) kPa, LESL (3.5 ± 1.32) cm, and Hp positive LESP (4.33 ± 0.77) cm ^ ) kPa and LESL (3.2 ± 1.36) cm respectively. There was no significant difference between before treatment and after treatment (all P> 0.05). Conclusion: Eradication of Hp has no significant effect on esophageal motility in patients with peptic ulcer.