论文部分内容阅读
目的了解肺炎克雷伯菌在儿科普通病房、新生儿病房、小儿重症监护病房(PICU)的临床分布特点和耐药情况,为临床合理用药提供依据。方法对本院2011年1月1日至2015年12月31日儿科各病房采集到的标本进行分析,菌株鉴定采用法国生物梅里埃公司的VITEK 2COMPACT分析仪,药敏试验采用MIC法。结果本院儿科各病房共分离到487株肺炎克雷伯菌,主要来自痰液和鼻咽拭子;各病区中产ESBLs的肺炎克雷伯菌检出率在35.3%~42.7%之间。药敏结果显示,产ESBLs肺炎克雷伯菌对氨苄西林、头孢菌素类、氨曲南100%耐药,对碳青霉烯类、氨基糖甙类、喹诺酮类抗菌药物敏感;未产ESBLs菌株耐药率相对较低。结论加强肺炎克雷伯菌的分离鉴定及耐药性的测定,是临床合理应用抗生素的重要依据。
Objective To understand the clinical distribution and drug resistance of Klebsiella pneumoniae in pediatric general ward, newborn ward and pediatric intensive care unit (PICU), and provide the basis for clinical rational drug use. Methods The specimens collected from each ward of our hospital from January 1, 2011 to December 31, 2015 were analyzed. The strains were identified by the VITEK 2COMPACT analyzer of BioMerieux, France, and the susceptibility test was performed by the MIC method. Results A total of 487 strains of Klebsiella pneumoniae were isolated from each ward of pediatric hospital, mainly from sputum and nasopharyngeal swabs. The detection rates of Klebsiella pneumoniae producing ESBLs in each ward ranged from 35.3% to 42.7%. Drug susceptibility results showed that ESBLs-producing Klebsiella pneumoniae was 100% resistant to ampicillin, cephalosporins and aztreonam and sensitive to carbapenems, aminoglycosides and quinolone antibiotics; ESBLs not produced Resistant strains are relatively low. Conclusion Strengthening the isolation and identification of Klebsiella pneumoniae and determination of drug resistance is an important basis for clinically rational use of antibiotics.