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吡美诺抑制兔子心房肌快速内向电流,延长心房动作电位时间,提示有对抗心房颤动的作用。对于狗,吡美诺能使乌头碱诱发心房颤动转为窦性节律。本文旨在研究吡美诺在临床心房颤动中急性效应。病人和方法:研究对象包括40例心房颤动发生后48小时以内来急诊室就诊的患者,有充血性心力衰竭、正在服用抗心律失常药或怀疑有窦房结或房室传导障碍者均予除外。病人被随机分为吡美诺组和安慰剂组,双盲给药,分别单剂注射吡美诺50mg(5ml)或5ml生理
Pimecline inhibition of rabbit atrial intima rapid inward current, prolonged atrial action potential time, suggesting that there is a role in the fight against atrial fibrillation. For dogs, pimecline can aconitine-induced atrial fibrillation into sinus rhythm. This article aims to investigate the acute effects of pimecline in clinical atrial fibrillation. PATIENTS AND METHODS: Subjects included 40 patients who visited the emergency department within 48 hours of the onset of atrial fibrillation, had congestive heart failure, were taking antiarrhythmic drugs, or were suspected of having sinus node or atrioventricular conduction disorders . The patients were randomized to either the Pimenone group or the placebo group and were given double-blind, single-dose of pimecrolimol 50 mg (5 ml) or 5 ml of physiology