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[目的]通过对从事林区野外工作者人粒细胞无形体病血清学调查,发现2例被蜱叮咬后发病住院的病例,结合回顾性临床和流行病学调查结果,修正诊断为人粒细胞无形体感染。为进一步开展调查和制定防控措施提供依据。[方法]应用间接免疫荧光法(IFA)检测人粒细胞无形体IgG抗体,对阳性人群逐一进行蜱叮咬史等及临床资料调查,核对住院或门诊病历。[结果]2例住院患者均有明确被蜱叮咬史和较典型的临床症状体征,诊断为“昆虫咬伤伴感染和发热待查”。经抗生素治疗痊愈。目前血清学检测人粒细胞无形体IgG抗体滴度分别为1∶64和1∶128,其中1例莱姆病和恙虫病抗体均阳性,另1例恙虫病抗体阳性。修正诊断为“人粒细胞无形体感染合并莱姆病、恙虫病混合感染”。[结论]武夷山林区有嗜粒细胞无形体感染病例,应进一步在该区开展粒细胞无形体病病原和疫源地等调查。
[Objective] To investigate the serological investigation of human granulocytic anaplasmosis in field work in forest area and found that two cases were hospitalized with tick bite and found retrospective clinical and epidemiological investigation results, the diagnosis of human granulocyte invisible Body infection. Provide evidence for further investigation and formulation of prevention and control measures. [Method] Indirect immunofluorescence assay (IFA) was used to detect the human IgG antibodies to human granulocyte. The ticks bites and the clinical data were investigated one by one in the positive population, and the inpatient or outpatient records were checked. [Results] All the 2 hospitalized patients had a clear history of tick bites and more typical clinical symptoms and signs, which was diagnosed as “insect bite with fever and infection”. Healed by antibiotic treatment. Currently serological detection of human myeloid placental IgG antibody titers were 1:64 and 1:128, respectively, of which 1 case of Lyme disease and scrub typhus antibodies were positive, and the other was positive for scrub typhus. Modified diagnosis of “human granulocyte apomixis infection with Lyme disease, scrub typhus mixed infection.” [Conclusion] In Wuyishan forest area, there is a case of infection of Acytophthora somaphalansis, and further investigations should be carried out on the pathogen and the source of Asexoplasmosis in this area.