【摘 要】
：
In a continuing search for biological natural products with structure diversity from traditional Chinese herbs,five new sesquineolignans(1-5)were isolated from an ethyl acetate extract of the twigs of Litsea cubeba.Their structures were elucidated based o
【机 构】
：
Key Laboratory of Chinese Internal Medicine of Ministry of Education and Beijing,Dongzhimen Hospital
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In a continuing search for biological natural products with structure diversity from traditional Chinese herbs,five new sesquineolignans(1-5)were isolated from an ethyl acetate extract of the twigs of Litsea cubeba.Their structures were elucidated based on MS,1D and 2D NMR spectroscopic data,as well as experimental electronic circular dichroism(ECD)spectra.Compounds 1-5 showed moderate inhibitory effects against LPS-induced NO production in RAW264.7 macrophages,with IC50 values of 16.2,20.2,22.1,15.1,and 16.6 μmol·L-1,respectively.
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