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目的:探讨高频振荡通气(HFOV)治疗重度新生儿呼吸衰竭的临床疗效。方法:选取确诊为重度呼吸衰竭的60例患儿作为研究对象,随机分为治疗组30例,对照组30例,治疗组采用高频震荡通气治疗(HFOV组),对照组采用常频机械通气(CMV)治疗(CMV组)。结果:HFOV组临床治疗效果明显好于CMV组,差异有统计学意义(P<0.01);经过6 h治疗,HFOV组28例存活患儿的氧浓度(FiO2)、氧合指数(OI)逐渐下降,动脉/肺泡氧分压(a/APO2)逐渐上升,各项指标与治疗前比较差异有统计学意义(P<0.05)。治疗12、24 h后,变化更为明显(P<0.01);存活患儿的氧气治疗时间、上机时间和住院时间方面比较,HFOV组明显短于CMV组,差异有统计学意义(P<0.01)。结论:高频振荡通气治疗新生儿呼吸衰竭有着十分重要的作用,它能够快速降低FiO2、OI,提高a/APO2,并有效防止并发症的发生,其疗效明显优于常频机械通气,因此具有很好的临床使用价值。
Objective: To investigate the clinical effect of high frequency oscillatory ventilation (HFOV) in the treatment of severe neonatal respiratory failure. Methods: Sixty children diagnosed with severe respiratory failure were randomly divided into treatment group (n = 30) and control group (n = 30). The treatment group was treated by high frequency oscillatory ventilation (HFOV group) (CMV) treatment (CMV group). Results: The therapeutic effect in HFOV group was significantly better than that in CMV group (P <0.01). After 6 h of treatment, the oxygen concentration (FiO2) and oxygenation index (OI) of 28 survivors in HFOV group gradually increased (A / APO2) of arterial / alveolar type increased gradually, and there was a significant difference between each index and before treatment (P <0.05). After treatment for 12 and 24 h, the changes were more obvious (P <0.01). Compared with the CMV group, the oxygen treatment time, on-machine time and hospital stay of surviving children were significantly shorter (P < 0.01). Conclusion: High-frequency oscillatory ventilation plays a very important role in the treatment of neonatal respiratory failure. It can reduce FiO2 and OI rapidly and a / APO2 and prevent the complications effectively. The curative effect is obviously better than that of normal-frequency mechanical ventilation, Good clinical value.