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目的研究有创与无创序贯性机械通气治疗慢性阻塞性肺疾病(chronic obstructive pulmonary diseases,COPD)所致严重呼吸衰竭(respiratory failure,RF)的治疗效果。方法选取COPD所致严重RF患者180例,随机均分为2组(n=90)。对照组运用有创机械通气治疗,观察组应用有创与无创序贯性机械通气治疗,分析2组疗效。结果治疗组患者肺通气功能明显高于对照组,差异有统计学意义(P<0.05),治疗组患者治疗15 d后与治疗7 d后肺通气功能差异有统计学意义(P<0.05),肺换气功能的比较,治疗组COPD患者明显高于对照组COPD患者,差异有统计学意义(P<0.05),治疗组患者治疗15 d后与治疗7 d后肺换气功能比较,差异有统计学意义(P<0.05)。结论有创与无创序贯性机械通气治疗COPD所致严重RF的患者具有很好的临床疗效,并且具有良好的安全性,目前已经成为治疗COPD所致严重RF患者的主要方法,对我国治疗COPD所致严重RF的发展具有重要价值,值得临床借鉴和推广。
Objective To investigate the therapeutic effect of invasive and non-invasive sequential mechanical ventilation on severe respiratory failure (COPD) caused by chronic obstructive pulmonary disease (COPD). Methods 180 patients with severe RF caused by COPD were randomly divided into 2 groups (n = 90). The control group was treated with invasive mechanical ventilation, and the observation group was treated with invasive and noninvasive sequential mechanical ventilation. The curative effect of the two groups was analyzed. Results The pulmonary function of patients in the treatment group was significantly higher than that of the control group (P <0.05). The pulmonary function of the patients in the treatment group after 15 days of treatment and after 7 days of treatment was significantly different (P <0.05) Compared with COPD patients in the treatment group, COPD patients in the treatment group were significantly higher than the COPD patients in the control group (P <0.05), and there was significant difference in the lung ventilation function between the 15-day treatment group and the 7-day treatment group Statistical significance (P <0.05). Conclusions Both invasive and noninvasive sequential mechanical ventilation have a good clinical effect in the treatment of severe RF caused by COPD and have good safety. At present, it has become the main method for the treatment of severe RF caused by COPD. Due to the development of severe RF has important value, it is worth clinical reference and promotion.