本文报告8例肾功能衰竭(肾衰)患者发生甘露醇中毒。男5例,女3例,年龄20～72岁。2例为慢性肾衰(1例为脑肿瘤水肿,1例为急性青光眼),6例为急性肾衰。全部病人均在1～3天内接受大量(有时为极大量)甘露醇静脉输入,平均用量为310±182.8g 或1,703±1,004.7mOsm。中毒表现为中枢神经系统抑制、意识模糊、嗜睡、昏睡及昏迷、体液过多(水肿、肺底啰音、急性充血性心力衰竭及肺水肿)、严重低钠血症、血渗透压增高、渗透压间隙(测得渗透压减去计算渗透压,可作为估计甘露醇浓度的指标)加大等。6例用血液透析治疗,1例用腹 This article reports the occurrence of mannitol intoxication in 8 patients with renal failure (renal failure). 5 males and 3 females, aged 20 to 72 years old. 2 were chronic renal failure (1 with brain tumor edema, 1 with acute glaucoma) and 6 with acute renal failure. All patients received a large amount (sometimes very large amount) of mannitol intravenously within 1 to 3 days at an average dose of 310 ± 182.8 g or 1,703 ± 1,004.7 mOsm. Intoxication showed central nervous system depression, drowsiness, lethargy and coma, excessive fluid (edema, pulmonary ailments, acute congestive heart failure and pulmonary edema), severe hyponatremia, increased blood osmotic pressure, infiltration Pressure gap (measured by reducing the osmotic pressure calculated osmotic pressure, which can be used as an indicator of estimated mannitol concentration) and so on. 6 cases hemodialysis treatment, 1 case with abdominal