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为了探讨碱性成纤维细胞生长因子 (bFGF)对特发性少弱精子症患者的作用 ,本研究对 5 7例确诊为特发性少弱精子症的患者用bFGF治疗 ,分别在治疗前后进行血生殖激素测定和精液质量分析。结果发现治疗后血生殖激素 (PRL、FSH、LH、T)水平升高 ,精子密度及顶体酶活性显著提高 (P <0 .0 1) ,精子活动力和成活率上升、畸形率下降 (P <0 .0 5 ) ,生育能力提高。因此认为bFGF是治疗特发性少弱精子症的有效药物
In order to investigate the role of basic fibroblast growth factor (bFGF) in patients with idiopathic oligoasthenospermia, 57 patients with idiopathic oligoasthenospermia were treated with bFGF before and after treatment Blood reproductive hormones and semen quality analysis. The results showed that after treatment, the levels of PRL, FSH, LH and T increased, the sperm density and acrosin activity increased significantly (P <0.01), the sperm motility and survival rate increased, and the deformity rate decreased P <0. 05), fertility increased. Therefore, bFGF is considered an effective drug for the treatment of idiopathic oligoasthenospermia