新生期去胸腺小鼠是经典的细胞免疫缺陷型动物模型,现已有裸鼠和重建型B鼠可代替。但新生期去胸腺方法比较简便,故目前国内外仍在应用。在国内尚不能广泛应用裸鼠和重建型B鼠的情况下,该方法有一定实用意义。我们对这一方法作了改进,并观察了不同日龄去胸腺对小鼠抗体反应能力和外周血T细胞数量的影响。 Neonatal thymus-depleted mice are classical animal models of cellular immunodeficiency. Nude mice and reconstructed B mice can now be substituted. However, the method of removing thymus during the neonatal period is relatively simple, so it is still being applied at home and abroad. This method has certain practical significance in the case that nude mice and reconstructed B mice cannot be widely used in China. We have improved this method and observed the effect of thymus desensitization at different ages on mouse antibody response and peripheral blood T cell numbers.