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为评价氯霉素对着床前胚泡的遗传毒性作用，Wistar大鼠在妊娠d3ip氯霉素65mg／kg，165mg／kg，330mg／kg。孕鼠于妊娠d4处死取胚泡，观察微核率，具微核胚泡率及有关丝分裂指数等。结果表明氛霉素各剂量组的微孩率呈剂量依赖性增加，与对照组相比较均有极显著差异；具微核胚烟率与对照组相比无显著差异，但呈一定量效相关性；ip氯霉素330mg/kg时．平均细胞数显著减少，有丝分裂指数与对照相比较无显著差异。提示氯霉素对整体大鼠着床有胚胞具遗传毒性。
To assess the genotoxic effects of chloramphenicol on prenucleus blastocysts, Wistar rats were given d3ip chloramphenicol 65 mg / kg, 165 mg / kg, and 330 mg / kg during pregnancy. Pregnant mice were sacrificed at d4 of gestation to observe the rate of micronuclei, the rate of micronucleated blastocysts and mitotic index. The results showed that each dose of strychaomycin dose rate of micro-children increased in a dose-dependent manner, compared with the control group were significantly different; with the rate of micro-nucleated embryo compared with the control group no significant difference, but a certain amount of correlation Sex; when chloramphenicol 330mg / kg. The average number of cells was significantly reduced, mitotic index compared with the control no significant difference. Prompt chloramphenicol on the implantation of the whole rat embryos have genotoxicity.