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目的:观察黄连素和钙剂伍用治疗以长间歇(平均为4·33s)为特征的病态窦房结综合征疗效。方法:符合病窦综合征诊断患者8例,口服黄连素片0·4~0·6g,tid;谷维素0·06g,tid;1周后同时加用10%葡萄糖酸钙10ml加入5%葡萄糖或0·9%氯化钠溶液中稀释,静脉滴注8~10d。治疗前后分别作动态心电图检查,观察24h平均心率、24h总心搏数、≥2s长间歇持续时间、长间歇发生次数。结果:治疗后24h平均心率、24h总心搏数,分别由(53·0±11·27)次/min、(71972±25840)次增加至(56·75±6·11)次/min、(76875±15116)次,均P<0·05;≥2s长间歇持续时间、长间歇发生次数分别由(4·33±1·61)s、(2485±2916)次减少至(2·75±0·8)s,(428±523)次,P<0·05、P<0·01。结论:黄连素和钙剂伍用对窦房结功能的改善有一定作用。
OBJECTIVE: To observe the efficacy of combination of berberine and calcium in the treatment of sick sinus syndrome characterized by prolonged intermittent (average 4.33 s). Methods: Eight patients diagnosed with sick sinus syndrome, oral berberine tablets 0.4-4.0.6g, tid; oryzanol 0.06g, tid; after 1 week plus 10% calcium gluconate 10ml added 5% glucose or 0.9% sodium chloride solution diluted intravenous infusion of 8 ~ 10d. Before and after treatment, respectively, for dynamic ECG, 24h observation of the average heart rate, 24h total heart rate, ≥ 2s long intermittent duration, long intermittent occurrences. Results: The average heart rate at 24 hours and the total heart rate at 24h increased from (53.0 ± 11.27) / min and (71972 ± 25840) times to (56.75 ± 6.11) / min, respectively) (76875 ± 15116) times, both P <0 · 05; the duration of intermittent duration ≥2s and the number of long intermittent episodes decreased from (4.33 ± 1.61) s, (2485 ± 2916) to (2.75 ± 0 · 8) s, (428 ± 523) times, P <0 · 05, P <0 · 01. Conclusion: The use of berberine and calcium can improve the function of the sinus node.