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目的 探讨鼻咽癌中基膜表达与肿瘤生物学特性的关系。方法 采用免疫组化ABC法检测 60例鼻咽癌标本中层粘蛋白和Ⅳ型胶原的表达。结果 未分化癌的基膜表达明显不同于大圆形细胞癌 (P <0 0 5 ) ,均呈断续、缺失的改变 ,而大圆形细胞癌、低分化鳞癌则部分显示连续线状基膜。条索状、弥散性排列的癌实质基膜表达明显不同于巢状排列者 (P <0 0 5 )。此外 ,层粘蛋白和Ⅳ型胶原的表达在有无淋巴结转移两组间 ,差异也具有显著性意义 (P <0 0 5 )。结论 层粘蛋白和Ⅳ型胶原的表达可作为评估鼻咽癌细胞的分化、癌实质类型及淋巴结转移的有价值指标
Objective To investigate the relationship between the expression of basement membrane in nasopharyngeal carcinoma and tumor biological characteristics. Methods Immunohistochemical ABC method was used to detect the expression of middle mucin and type Ⅳ collagen in 60 cases of nasopharyngeal carcinoma. Results The expression of basilar membrane in undifferentiated carcinoma was significantly different from that in macrocellular carcinoma (P <0.05), showing intermittent and absent changes. However, the large circular cell carcinoma and poorly differentiated squamous cell carcinoma showed some continuous linear Basement membrane. The cord-like and diffusely arranged cancer parenchymal basement membrane was significantly different from the nested arrangement (P <0.05). In addition, the expression of laminin and type IV collagen in the presence or absence of lymph node metastasis between the two groups, the difference was also significant (P <0 05). Conclusion The expression of laminin and type Ⅳ collagen can be used as a valuable index to evaluate the differentiation of nasopharyngeal carcinoma cells, the type of carcinoma, and lymph node metastasis