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目的:观察陀螺旋转式立体定向放射治疗系统(陀螺刀)联合长春瑞滨、顺铂(NP)方案治疗局部晚期非小细胞肺癌(NSCLC)的临床疗效观察及毒副反应。方法:94例局部晚期NSCLC患者,先给予陀螺刀治疗,单次治疗剂量3.2-5.0 Gy,等剂量曲线50%-70%,计划靶体积(PTV)覆盖95%以上,总剂量35-50 Gy,治疗后进行NP方案化疗4-6个周期。与同期144例单纯陀螺刀治疗局部晚期NSCLC患者治疗结果相比较。结果:联合治疗的94例患者,近期有效率为86.17%(81/94),6、12和24个月生存率分别为86.17%(81/94)、60.64%(57/94)和36.17%(34/94),毒性反应较轻。同期单纯陀螺刀治疗患者,近期有效率为88.19%(127/144),6、12和24个月生存率分别为87.50%(126/144)、44.44%(64/144)和23.68%(33/144)。结论:陀螺刀联合NP方案是一种对局部晚期NSCLC比较有效的治疗方法,毒副反应较轻。
OBJECTIVE: To observe the clinical effects and toxicities and side effects of gyroscopic gyroscope combined with vinorelbine and cisplatin (NP) regimen in the treatment of locally advanced non-small cell lung cancer (NSCLC). Methods: Ninety-four patients with locally advanced NSCLC were treated with gyro knife. The single dose was 3.2-5.0 Gy and the isodose curve was 50% -70%. The planned target volume (PTV) coverage was over 95%, and the total dose was 35-50 Gy , After treatment of NP regimen 4-6 cycles. Compared with the treatment of 144 patients with locally advanced NSCLC in the same period. Results: The combined treatment of 94 patients, the immediate effect was 86.17% (81/94), 6,12 and 24 months survival rates were 86.17% (81/94), 60.64% (57/94) and 36.17% (34/94), less toxic reactions. In the same period, the effective rate was 88.19% (127/144) in the immediate course of treatment, and the survival rates at 6, 12 and 24 months were 87.50% (126/144), 44.44% (64/144) and 23.68% / 144). Conclusion: Gyro knife combined with NP regimen is a more effective treatment for locally advanced NSCLC with less toxic and side effects.