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背景角蛋白分析可区分前列腺癌的管腔细胞(K18)、中间细胞(K5/18)和基底细胞(K5/14)。目前认为,中间细胞是前列腺癌发生恶性转化的元凶,是前列腺癌发生激素非依赖性转化的前体细胞。我们证实了正常和恶性前列腺上皮组织内的中间细胞均表达HGF受体c-Met。方法三重染色法分析c-Me
Background Keratin analysis distinguishes between luminal cells (K18), intermediate cells (K5 / 18) and basal cells (K5 / 14) in prostate cancer. At present, the intermediate cells are the culprit of malignant transformation of prostate cancer and hormone-independent precursor cells of prostate cancer. We confirmed that the intermediate cells in both normal and malignant prostate epithelial tissues express the HGF receptor c-Met. Methods Triplet staining was used to analyze c-Me